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Resolution of racemic mixtures via lipase catalysis in organic solvents

โœ Scribed by Kirchner, Gerald; Scollar, Mark P.; Klibanov, Alexander M.


Book ID
120938418
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
734 KB
Volume
107
Category
Article
ISSN
0002-7863

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Resolution of rac-flurbiprofen, 2-fluoro-0t-methyi-[1,1'-biphenyl]-4-scetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized l