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Resolution of gossypol: Analytical and large-scale preparative HPLC on non-chiral phases

โœ Scribed by Matlin, S. A. ;Belenguer, A. ;Tyson, R. G. ;Brookes, A. N.

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
495 KB
Volume
10
Category
Article
ISSN
0935-6304

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โœฆ Synopsis

Racemic gossypol is resolved by HPLC of its amino acid ester

Schiff's base derivatives on non-chiral columns. This provides a rapid and accurate method for determination of optical purityon a small scale and, combined with hydrolysis and fractional crystallization, for the preparation of pure gossypol enantiomers on a multi-gram scale.

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