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Enantiomeric resolution of chiral sulfoxides on polysaccharide phases by HPLC

✍ Scribed by Stephen A. Matlin; M. Elizabeth Tiritan; Quezia B. Cass; Derek R. Boyd

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 361 KB
Volume: 8
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1996)8:1<147::aid-chir22>3.0.co;2-m

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✦ Synopsis

The enantiomeric resolution of c k a l sulfoxides was investigated on amylose (S)-a-methylbenzyl carbamate phase coated on aminopropylated 7 p,m silica with 500A diameter pores. Thls was shown to be very successful in the separation of alkyl/aryl, aryl/aryl, and non-aromatic sulfoxides. The effect of pore size using naked silica was also investigated, demonstrating that the pore size does not affect the resolution.

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