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Enantiomer separation of fungicidal triazolyl alcohols by normal phase HPLC on polysaccharide-based chiral stationary phases

✍ Scribed by Torsten Spitzer; Eiji Yashima; Yoshio Okamoto

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 150 KB
Volume: 11
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1999)11:3<195::aid-chir4>3.0.co;2-8

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✦ Synopsis

Three fungicidal triazolyl alcohols (triadimenol, hexaconazole, and cis/ trans-1-4-chlorophenyl-2-1H-1,2,4-triazol-1-yl-cycloheptanol) were completely separated into enantiomers by chiral HPLC using polysaccharide-based chiral stationary phases. A better separation was achieved on cellulose and amylose carbamate phases compared with a cellulose ester phase. Peak shapes were almost symmetrical except for two cases, where tailing of the first eluted enantiomer and unusual symmetric peak broadening were observed. The effect of eluents on enantioseparation was also investigated. Chirality 11:195-200, 1999.

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