𝔖 Bobbio Scriptorium
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Resistance to multiple chemotherapeutic agents in human cancer cells

✍ Scribed by Michael M. Gottesman; Ira Pastan

Book ID
119112166
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
661 KB
Volume
9
Category
Article
ISSN
0165-6147

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## Abstract The mechanisms whereby malignant cells become biochemically resistant to anti‐cancer drugs are surveyed, with emphasis on human tumors. Metho‐trexate is used as a model to illustrate the mechanisms of resistance that can occur, and how cells can increase their production of dihyrofolate