✦ LIBER ✦

Resistance of human tumors to cancer chemotherapeutic agents: An important research problem

✍ Scribed by Bertino, J. R.

Book ID: 102949710
Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 676 KB
Volume: 5
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950050117

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The mechanisms whereby malignant cells become biochemically resistant to anti‐cancer drugs are surveyed, with emphasis on human tumors. Metho‐trexate is used as a model to illustrate the mechanisms of resistance that can occur, and how cells can increase their production of dihyrofolate reductase, the target enzyme. Drug resistance remains one of the major impediments to the successful use of chemotherapy for neoplastic diseases.

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