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Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators

✍ Scribed by Peter Nygren; Rolf Larsson

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
793 KB
Volume
48
Category
Article
ISSN
0020-7136

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✦ Synopsis

DIFFERENTIAL CYTOTOXIC SENSITIVITY OF HUMAN NORMAL AND TUMOR CELLS 599 TABLE I -CHARACTERISTICS OF THE INVESTIGATED HUMAN CELL TYPES' ~ Cell type Origin Characteristic Type of culture Growth rate in vifro exDreSS,On Pgp, ACHN LO Lloo Fibroblasts Lymphocytes CLL, AML Cells from solid tnmors Kidney adenocarcinoma Acute T-cell lymphoblastic leukemia Vcr-resistant subline from LO Amniotic fluid Healthy blood donors Peripheral-blood samples from patients with leukemia Patients operated on for tumor resection Continuous cell line Doubling time 33 hr No Continuous cell line Doubling time 72 hr No Continuous cell line Doubling time 72 hr Yes Cell line, used at Doubling time 96 hr ND passages 3 to 12 Primary cultures No growth ND Primary cultures No growth ND Primary cultures No growth ND ~ 'Pgp expression accordlng to Nygren and Larsson, 1990.-ND, not done

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