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Resistance of teratocarcinoma stem cells to infection with simian virus 40: Early events

✍ Scribed by Douglas E. Swartzendruber; Thomas D. Friedrich; John M. Lehman

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 612 KB
Volume: 93
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040930105

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✦ Synopsis

Multipotential stem cells of a murine teratocarcinoma are resistant to typical infection with either polyoma virus (PV) or Simian virus 40 (SV,o). Differentiated progeny of the stem cells are susceptible to infection in a manner identical to other mouse somatic cells, i.e., they are permissive for PV and nonpermissive for SV,,. The early interactions between the stem cells (embryonal carcinoma or EC cells) and SV,, and PV were studied. Virions adsorbed to and penetrated into the cytoplasm and nucleus of EC cells, but did not induce

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