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Resistance of NIH3T3 Cells to v-fes Transformation Induced by a Dominant Negative H-ras Mutant

✍ Scribed by Yoshifumi Ogiso; Toichiro Yokoyama; Hidemiti Watari; Thomas Y. Shih; Noboru Kuzumaki


Book ID
115601569
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
514 KB
Volume
208
Category
Article
ISSN
0014-4827

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We examined the effects of the introduction of H-ras oncogene into murine cell line NIH3T3 on growth inhibition by topoisomerase-I (topo-I) inhibitors. The H-ras-transformed cells (pT22-3) showed approximately I 2-fold increased sensitivity to a novel topo-l inhibitor, NB-506 [6-N-formylamino-I2,I3d

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## Abstract Previous studies have revealed that p202 (52 kDa), an interferon (IFN) and differentiation‐inducible protein, negatively regulates cell proliferation and modulates cell survival. However, the role of p202 in transformed cells remains to be investigated. Here we report that constitutive