Resistance of NIH3T3 Cells to v-fes Transformation Induced by a Dominant Negative H-ras Mutant
β Scribed by Yoshifumi Ogiso; Toichiro Yokoyama; Hidemiti Watari; Thomas Y. Shih; Noboru Kuzumaki
- Book ID
- 115601569
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 514 KB
- Volume
- 208
- Category
- Article
- ISSN
- 0014-4827
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π SIMILAR VOLUMES
We examined the effects of the introduction of H-ras oncogene into murine cell line NIH3T3 on growth inhibition by topoisomerase-I (topo-I) inhibitors. The H-ras-transformed cells (pT22-3) showed approximately I 2-fold increased sensitivity to a novel topo-l inhibitor, NB-506 [6-N-formylamino-I2,I3d
## Abstract Previous studies have revealed that p202 (52 kDa), an interferon (IFN) and differentiationβinducible protein, negatively regulates cell proliferation and modulates cell survival. However, the role of p202 in transformed cells remains to be investigated. Here we report that constitutive