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Resistance mechanisms oftumourcells to EGFR inhibitors

✍ Scribed by Floriana Morgillo; Flavia Cantile; Morena Fasano; Teresa Troiani; Erika Martinelli; Fortunato Ciardiello

Book ID
107596506
Publisher
Springer Milan
Year
2009
Tongue
Spanish
Weight
557 KB
Volume
11
Category
Article
ISSN
1699-048X

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## Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that activates multiple signaling pathways, including phosphatidylinositol‐3‐kinase/v‐AKT murine thymoma viral oncogene homolog protein (Akt), has long been a target of novel therapies. Despite universal EGFR expression