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Acquired resistance to EGFR inhibitors: mechanisms and prevention strategies

✍ Scribed by Alicia M Viloria-Petit; Robert S Kerbel

Book ID
108148293
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
488 KB
Volume
58
Category
Article
ISSN
0360-3016

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## Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that activates multiple signaling pathways, including phosphatidylinositol‐3‐kinase/v‐AKT murine thymoma viral oncogene homolog protein (Akt), has long been a target of novel therapies. Despite universal EGFR expression