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Residual effects of prolonged cannabis administration on exploration and DRL performance in rats

✍ Scribed by Alexander Stiglick; Harold Kalant

Publisher
Springer
Year
1982
Tongue
English
Weight
519 KB
Volume
77
Category
Article
ISSN
0033-3158

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✦ Synopsis

Chronic oral administration of cannabis extract to rats (daily A 9-tetrahydrocannabinol dose 20 mg/kg) was examined for its residual effect on open field activity and DRL (differential reinforcement of low-rate responding) performance, following a 2-3-month drug-free period. Locomotor activity during the latter part of an open field test was markedly increased in rats previously treated for either 6 months or 3 months with the drug. The same treatments also produced a significant impairment on a DRL-20 task relative to control subjects' performance. These and other findings (impaired maze learning and facilitated two-way shuttle box avoidance) might mean that cannabis produces long-lasting hippocampal dysfunction in rats.

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