Chronic oral administration of cannabis extract to rats (daily A 9-tetrahydrocannabinol dose 20 mg/kg) was examined for its residual effect on open field activity and DRL (differential reinforcement of low-rate responding) performance, following a 2-3-month drug-free period. Locomotor activity durin
Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat
โ Scribed by Alexander Stiglick; Mark E. Llewellyn; Harold Kalant
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 419 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
โฆ Synopsis
Chronic oral administration of cannabis extract to rats was examined for its residual effects on shuttle-box avoidance learning. In experiment 1 avoidance learning was assessed in rats that had been tested previously on other behavioral tests. Chronic treatment (3 months) facilitated the learning of shuttle-box avoidance in cannabis-treated animals relative to vehicle controls. In experiment 2 very similar results were obtained in naive rats. These and other residual effects of chronic cannabis treatment are similar to the effects of hippocampal lesions.
๐ SIMILAR VOLUMES
The effects of ethanol on avoidanceavoidance conflict behavior were examined, utilizing a 3-x -3 factorial design in which rats were trained and tested after drinking sugar-water solutions containing 0, 3, or 6 % ethanol. Avoidance tendencies were established by initially training rats to escape fro
Rats were permitted to turn on and off electrical stimulation of the medial forebrain bundle, by alternating between two photobeams running along opposite walls of a shuttle box. Entry into one beam (the "ON" beam) triggered the delivery of a succession of short, regularly occurring (1 Hz) pulse tra