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Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 Adipocytes

✍ Scribed by K. Kotani; A.J. Carozzi; H. Sakaue; K. Hara; L.J. Robinson; S.F. Clark; K. Yonezawa; D.E. James; M. Kasuga


Book ID
115576441
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
354 KB
Volume
209
Category
Article
ISSN
0006-291X

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## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3‐L1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulin‐stimulated glucose uptake in a time‐ and dose‐dependent manner. Whereas