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Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes

✍ Scribed by Anne W Harmon; Yashomati M Patel

Book ID: 117053854
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 163 KB
Volume: 305
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(03)00720-4

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## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3‐L1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulin‐stimulated glucose uptake in a time‐ and dose‐dependent manner. Whereas