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ArPIKfyve–PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

✍ Scribed by Ognian C. Ikonomov; Diego Sbrissa; Rajeswari Dondapati; Assia Shisheva

Book ID
113955649
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
842 KB
Volume
313
Category
Article
ISSN
0014-4827

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## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3‐L1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulin‐stimulated glucose uptake in a time‐ and dose‐dependent manner. Whereas