Reproduction of occult metastasis of head and neck cancer in nude mice
β Scribed by Shuichi Kawashiri; Shigehiro Kumagai; Kiyoshi Kojima; Hiroki Harada; Kiyomasa Nakagawa; Etsuhide Yamamoto
- Book ID
- 110238744
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 106 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0262-0898
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## Abstract ## Background. Metastases are the primary cause of cancer treatment failure and death, yet metastatic mechanisms remain incompletely understood. ## Methods. We studied the molecular basis of head and neck cancer metastasis by transcriptionally profiling 70 samples from 27 patientsβma
This study was undertaken to investigate the potential role of xenografts established from human head and neck squamous cell carcinoma (HNSCC) in the selection of new anticancer agents for phase II clinical trials. Eight HNSCC tumor lines were established in NMRl nude mice. The tumor-bearing animals