Preclinical chemotherapy on human head and neck cancer xenografts grown in athymic nude mice

✍ Scribed by Dr. Boudewijn J. M. Braakhuis; Guus A. M. S. Van Dongen; Marian Bagnay; Marijke Van Walsum; Gordon B. Snow

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 506 KB
• Volume: 11
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.2880110607

✦ Synopsis

This study was undertaken to investigate the potential role of xenografts established from human head and neck squamous cell carcinoma (HNSCC) in the selection of new anticancer agents for phase II clinical trials. Eight HNSCC tumor lines were established in NMRl nude mice. The tumor-bearing animals were then treated with drugs at the maximum tolerated dose level. Treatment with drugs known for their activity in 15%-30% of HNSCC patients [cisplatin (CDDP), bleomycin (BLEO), 5-fluorouracil (5-Fu), cyclophosphamide (CY), and doxorubicin (DOX)] caused strong responses in up to 38% and moderate responses in 50%-67% of the HNSCC tumor lines. Methotrexate (MTX), known to cause remissions in about 40% of HNSCC patients, was only minimally active in this model system. A clinically ineffective drug, amsacrine (m-AMSA), was included as a negative control and showed no or minimal activity in all four HNSCC lines tested. A number of experimental drugs that have promising preclinical activity were also tested. Brequinar sodium (Dup 785) and 10-ethyl, 10-deaza-aminopterin (1 0-MAM) showed activity in three of five, and two of the four tested tumor