We report studies of the effect of ischemia on the metabolic activity of the intact perfused lung and its restoration after a period of reperfusion. Two groups of rat lungs were studied using hyperpolarized 1โ^13^C pyruvate to compare the rate of lactate labeling differing only in the temporal order
Reproducibility study for free-breathing measurements of pyruvate metabolism using hyperpolarized 13C in the heart
โ Scribed by Angus Z. Lau; Albert P. Chen; Jennifer Barry; John J. Graham; William Dominguez-Viqueira; Nilesh R. Ghugre; Graham A. Wright; Charles H. Cunningham
- Book ID
- 112147509
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 473 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0740-3194
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## Abstract [1โ^13^C]Pyruvate is a readily polarizable substrate that has been the subject of numerous magnetic resonance spectroscopy (MRS) studies of in vivo metabolism. In this work ^13^CโMRS of hyperpolarized [1โ^13^C]pyruvate was used to interrogate a metabolic pathway involved in neither aero
Fast chemical shift imaging (CSI) techniques are advantageous in metabolic imaging of hyperpolarized compounds due to the limited duration of the signal amplification. At the same time, reducing the acquisition time in hyperpolarized imaging does not necessarily lead to the conventional penalty in s