Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies
β Scribed by Albert P. Chen; John Kurhanewicz; Robert Bok; Duan Xu; David Joun; Vickie Zhang; Sarah J. Nelson; Ralph E. Hurd; Daniel B. Vigneron
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 417 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0730-725X
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With signalβtoβnoise ratio enhancements on the order of 10,000βfold, hyperpolarized MRSI of metabolically active substrates allows the study of both the injected substrate and downstream metabolic products __in vivo__. Although hyperpolarized [1β^13^C]pyruvate, in particular, has been used to demons
## Abstract Dynamic nuclear polarization can be used to increase the sensitivity of solution state ^13^C magnetic resonance spectroscopy by four orders of magnitude. We show here that [1β^13^C]glutamate can be polarized to 28%, representing a 35,000βfold increase in its sensitivity to detection at
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