With signalβtoβnoise ratio enhancements on the order of 10,000βfold, hyperpolarized MRSI of metabolically active substrates allows the study of both the injected substrate and downstream metabolic products __in vivo__. Although hyperpolarized [1β^13^C]pyruvate, in particular, has been used to demons
In vivo MRSI of hyperpolarized [1-13C]pyruvate metabolism in rat hepatocellular carcinoma
β Scribed by Moses M. Darpolor; Yi-Fen Yen; Mei-Sze Chua; Lei Xing; Regina H. Clarke-Katzenberg; Wenfang Shi; Dirk Mayer; Sonal Josan; Ralph E. Hurd; Adolf Pfefferbaum; Lasitha Senadheera; Samuel So; Lawrence V. Hofmann; Gary M. Glazer; Daniel M. Spielman
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 795 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.1616
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π SIMILAR VOLUMES
A single-voxel Carr-Purcell-Meibloom-Gill sequence was developed to measure localized T(2) relaxation times of (13)C-labeled metabolites in vivo for the first time. Following hyperpolarized [1-(13)C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the l
## Abstract We present for the first time dynamic spectra and spectroscopic images acquired in normal rats at 3T following the injection of ^13^Cβ1βpyruvate that was hyperpolarized by the dynamic nuclear polarization (DNP) method. Spectroscopic sampling was optimized for signalβtoβnoise ratio (SNR)
## Abstract [1β^13^C]Pyruvate is a readily polarizable substrate that has been the subject of numerous magnetic resonance spectroscopy (MRS) studies of in vivo metabolism. In this work ^13^CβMRS of hyperpolarized [1β^13^C]pyruvate was used to interrogate a metabolic pathway involved in neither aero
We report studies of the effect of ischemia on the metabolic activity of the intact perfused lung and its restoration after a period of reperfusion. Two groups of rat lungs were studied using hyperpolarized 1β^13^C pyruvate to compare the rate of lactate labeling differing only in the temporal order