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Replication of measles virus in cultured human thymic epithelial cells

✍ Scribed by Kei Numazaki; Hy Goldman; Inés Wong; Dr. Mark A. Wainberg

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
814 KB
Volume
27
Category
Article
ISSN
0146-6615

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✦ Synopsis

Measles virus can replicate in cultures of both infantile and fetal human thymic epithelial cells. Virus-induced cytopathology including syncytium formation was first evident around 24 hr after viral inoculation of these cultures. At the same time, the cultures began to lose their characteristic thymus-like organizational structure. Viral antigens were detected in infected cells by indirect immunofluorescence, and the presence of progeny virions was demonstrated in culture fluids.

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