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Differences in Metabolism of Chemical Carcinogens in Cultured Human Epithelial Tissues and Cells

โœ Scribed by Curtis C. Harris; Benjamin F. Trump; Roland Grafstrom; Herman Autrup

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
561 KB
Volume
18
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

Abstract

The metabolism of chemical carcinogens has been studied in cultured human bronchus, colon, duodenum, pancreatic duct, and esophagus. Metabolite patterns and carcinogenโ€DNA adducts are generally qualitatively similar among animal species, individuals within a species, and tissues within an individual. However, wide quantitative differences are observed between individuals in outโ€bred animal species, including humans. These interindividual differences in amounts of carcinogenโ€DNA adducts and in activities of enzymes that are important in the metabolism of chemical carcinogens are similar in magnitude (10โ€to 150โ€fold) to those observed in pharmacogenetic studies of drug metabolism. The role of these differences as risk factors in human cancer is being investigated.

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