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Repeated use of L-asparaginase in multi-drug therapy of childhood leukemia

✍ Scribed by Trueworthy, Robert C. ;Sutow, Wataru W. ;Pullen, Jeanette ;Komp, Diane ;Berry, D. H.

Book ID
102525047
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
370 KB
Volume
4
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

The capacity of l‐asparaginase in two separate schedules (consecutive and intermittent), along with vincristine and prednisone to produce multiple responses, was evaluated in previously treated children with acute leukemia in relapse. The response rates varied inversely with previous l‐asparaginase exposure. A history of prior resistance to prednisone and vincristine appeared to reduce the response rate. Hypersensitivity reactions occurred in 14%.

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