Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia

✍ Scribed by Sutow, Wataru W. ;George, Stephen ;Lowman, James T. ;Starling, Kenneth A. ;Humphrey, G. Bennett ;Haggard, Mary Ellen ;Vietti, Teresa J.

• Book ID: 102949948
• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 524 KB
• Volume: 2
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950020405

✦ Synopsis

Abstract

Six regimens utilizing L‐asparaginase in doses of 6,000 IU/M^2^, 2,000 IU/M^2^, and 500 IU/M^2^ in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse. The addition of daunorubicin to one regimen did not alter the response rate. Hypersensitivity reactions occurred in 5% and hyperglycemia in 7%. Lower doses of L‐asparaginase significantly reduced the hypersensitivity rate but no such pattern was noted for hyperglycemia. A history of prior resistance to prednisone and vincristine significantly reduced the response rate.