Repeated administration of subconvulsant
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David J. Nutt; Philip J. Cowen; Celia C. Batts; David G. Grahame-Smith; A. Richa
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Article
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1982
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Springer
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English
β 377 KB
Repeated subconvulsant doses of the GABA antagonist drugs picrotoxin (5mg/kg), pentylenetetrazol (PTZ) (30mg/kg), and bicuculline (3.5 mg/kg), were given IP once daily to rats. Picrotoxin produced rapid kindling to full seizures in about 5 days, PTZ produced sporadic myoclonic seizures after 17 days