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Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway

โœ Scribed by Steven D. Bruner; Huw M. Nash; William S. Lane; Gregory L. Verdine


Book ID
114321077
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
192 KB
Volume
8
Category
Article
ISSN
0960-9822

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr