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Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae

✍ Scribed by Michelle Hanna; Barbara L Chow; Natalie J Morey; Sue Jinks-Robertson; Paul W Doetsch; Wei Xiao


Book ID
116410177
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
188 KB
Volume
3
Category
Article
ISSN
1568-7864

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr