Renal contribution to overall metabolism of drugs III: Metabolism of p-aminobenzoic acid

✍ Scribed by Suk Han Wan; Bernd Von Lehmann; Sidney Riegelman

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 566 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610824

✦ Synopsis

The metabolic processes involved in the conversion of p-aminobenzoic acid to p-acetamidobenzoic acid, p-aminohippuric acid, and p-acetarnidohippuric acid in the rabbit were reanalyzed. The contribution made by the kidney to the overall metabolism was estimated from analysis of clearance data.

Keyphrases .Q p-Aminobenzoic acid-metabolism, disposition kinetics, reevaluation of contribution of kidney to clearance c] p-Acetamidobenzoic acid as p-aminobenzoic acid metabolite-renal metabolism and clearance, apparent clearance, role of kidney reevaluated 0 p-Aminohippuric acid as p-aminobenzoic acid metabolite-renal metabolism and clearance, apparent clearance, role of kidney reevaluated 0 p-Acetamidohippuric acid as p-aminobenzoic acid metabolite-renal metabolism and clearance, apparent clearance, role of kidney reevaluated 0 Drug metabolismrole of kidney in p-aminobenzoic acid metabolism reevaluated from analysis of clearance data p-Aminobenzoic acid occurs widely in nature and has been the subject of much interest since the discovery that it antagonizes the action of sulfonamides. It