Renal contribution to overall metabolism of drugs I: Conversion of benzoic acid to hippuric acid

✍ Scribed by Suk Han Wan; Sidney Riegelman

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 757 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610822

✦ Synopsis

The kinetics of biotransformation of benzoic acid t o hippuric acid during infusion in animals were studied a t steady state. The contributions to the glycine conjugation of benzoic acid made by the kidney in contrast to the body as a wh.ole were quantified by the utilization of apparent clearances, ( Vr~)app., and true renal clearances, ( V&.. Michaelis-Menten kinetics appear to describe the rate of biotransformation of both metabolic processes.

The data result in estimation of the in oico K, and V,,,. values.

Keyphrases a Benzoic acid biotransformation to hippuric acidkidney metabolism contribution contrasted to whole body, renal and apparent clearances 0 Hippuric acid from benzoic acid biotransformation-kidney metabolism contrasted to whole body, renal and apparent clearances 0 Kidney metabolism-contribution to biotransformation of benzoic acid to hippuric acid, contrasted with whole body, renal and apparent clearances 0 Biotransformation kinetics--benzoic acid to hippuric acid, kidney metabolism contribution