✦ LIBER ✦

Remission induction with L-asparaginase, vincristine, and prednisone in children with acute nonl ymphoblastic leukemia

✍ Scribed by Land, Vita J. ;Sutow, Wataru W. ;Dyment, Paul G. ;Falletta, John M. ;Morgan, Samuel K. ;Bryan, J. Hugh

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 522 KB
Volume: 2
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950020209

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✦ Synopsis

Abstract

Forty‐five children with acute nonlymphoblastic leukemia in relapse received a total of 56 courses of L‐asparaginase combined with vincristine and prednisone. The complete remission rate of 40% (12 of 30 trials) in patients resistant to vincristine and prednisone was almost identical to that in children still sensitive to vincristine and prednisone (42%, 11 of 26 trials). The complete remission rate of 38% (14 of 37 exposures) in those children who had not received L‐asparaginase previously compared favorably with the complete remission rate in those children who had received prior L‐asparaginase (47%, 9 of 19 exposures). Forty‐seven of the 56 induction trials were in children with 1 or more remissions and 14 of these were in children with 3 or more prior remissions. Toxicity was minimal.

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