Courses of cytosine arabinoside followed by L-asparaginase were administered for 4 days each to 17 children with previously treated acute lymphatic leukemia, at 14to 27-day intervals. Complete or partial remission occurred in 81% of patients after the third or fourth course of therapy. Rlaintenance
Induction of remission with l-asparaginase, cyclophosphamide, cytosine arabinoside, and prednisolone in adult patients with acute leukemia
✍ Scribed by G. Gahrton; L. Engstedt; S. Franzén; B. Gullbring; G. Holm; S. Höglund; A. Killander; D. Killander; D. Lockner; H. Mellstedt; J. Palmblad; P. Reizenstein; K-O. Skarberg; B. Swedberg; A-M. Udén
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 650 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Eleven patients with acute lymphocytic leukemia in relapse were treated with L‐asparaginase and cytosine arabinoside (1‐β‐D‐arabinofuranosylcytosine) in induction therapy and the same drugs plus cyclophosphamide in maintenance therapy. Three patients had complete remissions lasting 6, 1
## Abstract Ten patients with late‐stage acute lymphocytic leukemia were treated with L‐asparaginase and cytosine arabinoside. Complete remission was achieved in 8 patients including 5 of 5 patients with T‐cell leukemia. Major toxicity included anaphylactic reactions in 3 of the 10 patients.
Forty-six previously untreated patients with acute nonlymphocytic leukemia were treated with a remission induction regimen consisting of three daily doses of Adriamycin (30 mg/m2/day) and a ten-day continuous infusion of cytosine arabinoside (ara C) (100 mg/m2/day). The overall remission rate was 72
## Abstract ## BACKGROUND: The optimal postremission therapy in adults with acute lymphoblastic leukemia (ALL) is still a matter of debate. The objective of this study was to compare the various potential therapeutic options for patients who achieved first complete remission. ## METHODS: The aut