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Vincristine, prednisone and L-asparaginase in the induction of remission in children with acute lymphoblastic leukemia following relapse

✍ Scribed by F. H. Kung; W. L. Nyhan; J. Cuttner; G. Falkson; P. Lanzkowsky; V. Del Duca; I. U. Nawabi; K. Koch; H. Pluess; A. Freeman; E. O. Burgert; L. A. Leone; F. Ruymann; R. B. Patterson; T. Degnan; N. Hakami; T. F. Pajak; James Holland


Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
548 KB
Volume
41
Category
Article
ISSN
0008-543X

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Vincristine and prednisone vs vincristin
✍ Herson, Jay ;Starling, Kenneth A. ;Dyment, Paul G. ;Humphrey, G. Bennett ;Pullen πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 332 KB

Second remission induction rates for vincristine and prednisone alone (VP) and vincristine, L-asparaginase, and prednisone (VLP) are compared for children with acute lymphocytic leukemia. No evidence of a significant difference between the second induction complete remission rate for VP (78.6%) and

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Therapy for acute lymphocytic leukemia (ALL) has been less successful in adults than in children. Many centers treat all adult leukemia with the same regimen. We have used vincristine and prednisone for initial therapy in 14 adults with ALL since 1971 and have followed a treatment regimen developed

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A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction. The more intensive regimen was associated with a lower complete remission rate (81% vs 93%) and a higher early

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## Abstract ## BACKGROUND. The authors evaluated the response rate, toxicity, and pharmacokinetics of topotecan given before standard induction therapy for childhood acute lymphoblastic leukemia (ALL) in first relapse. ## METHODS. Patients received topotecan (2.4 mg/m^2^ daily as a 30‐minute inf