## Abstract Three therapeutic regimens (6βhr intervals for 6 doses daily for 3 days, and a single infusion) utilizing the same total dose of adriamycin for the induction of remission in children with lateβstage acute leukemia were evaluated in 150 patients. Complete remission rates were 15%, 28%, a
Remission induction in acute myelogenous leukemia using cytosine arabinoside synchronization: A southwest oncology group study
β Scribed by Steuber, C. Philip ;Humphrey, G. Bennett ;McMillan, Campbell W. ;Vietti, Teresa J.
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 353 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0098-1532
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β¦ Synopsis
The use of cytosine arabinoside (Ara-C) infused at kinetically suggested intervals is reported in 40 pediatric patients with acute myelogenous leukemia (AML) and its subtypes. Response was observed in 17 of the 34 evaluable patients. However, the severe, often fatal effects of the regimen prevent its recommendation as a standard induction regimen in AML in children.
π SIMILAR VOLUMES
Five weekly doses of triple intrathecal (IT) chemotherapy (methotrexate, hydrocortisone, cytosine arabinoside) starting on day 1 of treatment were added to systemic induction therapy in a regimen (Arm 3) that was compared to three other regimens (Arms 1, 2, and 4) in which central nervous system (CN