The use of aluminum chloride for removal
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Kenneth D. James; Andrew D. Ellington
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Article
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1998
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Elsevier Science
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French
β 186 KB
A method for the facile removal of the t-butoxycarbonyl (Boc) group with aluminum chloride during solidphase oligonucleotide synthesis is presented The method enables the common amino protecting group, which is stable to base and weak acid, to be removed with no threat to the integrity of the oligon