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The use of aluminum chloride for removal of Boc groups on 5′-amino-2′,5′-dideoxyoligonucleotides during solid-phase synthesis

✍ Scribed by Kenneth D. James; Andrew D. Ellington

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 186 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10509-3

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✦ Synopsis

A method for the facile removal of the t-butoxycarbonyl (Boc) group with aluminum chloride during solidphase oligonucleotide synthesis is presented The method enables the common amino protecting group, which is stable to base and weak acid, to be removed with no threat to the integrity of the oligonucleotide. The suitability of several other Lewis acids for this procedure is discussed

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