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The use of aluminum chloride for removal of Boc groups on 5′-amino-2′,5′-dideoxyoligonucleotides during solid-phase synthesis

✍ Scribed by Kenneth D. James; Andrew D. Ellington


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
186 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


A method for the facile removal of the t-butoxycarbonyl (Boc) group with aluminum chloride during solidphase oligonucleotide synthesis is presented The method enables the common amino protecting group, which is stable to base and weak acid, to be removed with no threat to the integrity of the oligonucleotide. The suitability of several other Lewis acids for this procedure is discussed


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