Release of testosterone from an osmotic pump tablet utilizing (SBE)7m-β-cyclodextrin as both a solubilizing and an osmotic pump agent
✍ Scribed by Kazuto Okimoto; Roger A. Rajewski; Valentino J. Stella
- Book ID
- 114163665
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 263 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0168-3659
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📜 SIMILAR VOLUMES
The objective of this work was to demonstrate that the incorporation of sulfobutylether-beta-cyclodextrin, (SBE)(7M)-beta-CD, results in the complete and sustained release of a sparingly water-soluble drug, prednisolone (PDL) from controlled porosity-osmotic pump pellets (CP-OPP). PDL and CD were pr
Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB