The objective of this work was to demonstrate that the incorporation of sulfobutylether-beta-cyclodextrin, (SBE)(7M)-beta-CD, results in the complete and sustained release of a sparingly water-soluble drug, prednisolone (PDL) from controlled porosity-osmotic pump pellets (CP-OPP). PDL and CD were pr
✦ LIBER ✦
Release mechanisms of a sparingly water-soluble drug from controlled porosity-osmotic pump pellets using sulfobutylether-β-cyclodextrin as both a solubilizing and osmotic agent
✍ Scribed by Sutthilug Sotthivirat; John L. Haslam; Ping I. Lee; Venkatramana M. Rao; Valentino J. Stella
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 161 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0022-3549
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Controlled porosity-osmotic pump pellets
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Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB