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Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)7m-β-CD as both a solubilizer and osmotic agent

✍ Scribed by Kazuto Okimoto; Atsuo Ohike; Rinta Ibuki; Osamu Aoki; Norio Ohnishi; Roger A. Rajewski; Valentino J. Stella; Tetsumi Irie; Kaneto Uekama


Book ID
114163780
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
684 KB
Volume
60
Category
Article
ISSN
0168-3659

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✍ Sutthilug Sotthivirat; John L. Haslam; Valentino J. Stella 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 1 views

The objective of this work was to demonstrate that the incorporation of sulfobutylether-beta-cyclodextrin, (SBE)(7M)-beta-CD, results in the complete and sustained release of a sparingly water-soluble drug, prednisolone (PDL) from controlled porosity-osmotic pump pellets (CP-OPP). PDL and CD were pr