Release of taurine in apoptotic cerebellar granule neurons in culture
✍ Scribed by J. Morán; X. Hernández-Pech; H. Merchant-Larios; H. Pasantes-Morales
- Book ID
- 106111794
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 852 KB
- Volume
- 439
- Category
- Article
- ISSN
- 0031-6768
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Effects of increased concentrations of potassium and of hyposmolar conditions on release of taurine were investigated in cerebellar granule neurons cultured from mice. It was found that increases in the external potassium concentration as well as decreases in osmolarity dose-dependent1 y increased r
When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300
## Abstract Cultured rat cerebellar granule neurons exposed to solutions of reduced osmolarity, responded initially by swelling followed by a regulatory volume decrease (RVD) which is completed within 15 min. Increasing external osmolarity lead to cell shrinking but no evidence of volume regulation
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