## Communicated by Ulf Landegren Duchenne and Becker muscular dystrophy (DMD and BMD) are caused by mutations in the dystrophin gene. Large rearrangements in the gene are found in about two-thirds of DMD patients, with B60% carrying deletions and 5-10% carrying duplications. Most of the remaining
Relatively low proportion of dystrophin gene deletions in Israeli Duchenne and Becker muscular dystrophy patients
β Scribed by Shomrat, Ruth ;Gluck, Eithan ;Legum, Cyril ;Shiloh, Yosef
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 535 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0148-7299
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We studied 48 patients with dystrophinopathies (29 Duchenne muscular dystrophy (DMD), 13 Becker muscular dystrophy (BMD), four possible carriers, one female with DMD, and one intermediate form, using polymerase chain reaction (PCR) analysis of muscle tissue for 20 exons and compared them with immuno
We have analyzed 59 unrelated Mexican Duchenne/Becker muscular dystrophy patients (DMD/BMD) using PCR analysis of the 2 prone deletion regions in the DMD gene. Thirty one (52%) of the patients had a deletion of one or several of the exons. Most of the alterations (87%) were clustered in exons 44-52,