DNA polymorphisms and deletion analysis of the Duchenne-Becker muscular dystrophy gene in the chinese
β Scribed by Soong, Bing-Wen ;Tsai, Ting-Fen ;Su, Chume-Hwae ;Kao, Ko-Pei ;Hsiao, Kwang-Jen ;Su, Tsung-Sheng
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 758 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0148-7299
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## Communicated by Ulf Landegren Duchenne and Becker muscular dystrophy (DMD and BMD) are caused by mutations in the dystrophin gene. Large rearrangements in the gene are found in about two-thirds of DMD patients, with B60% carrying deletions and 5-10% carrying duplications. Most of the remaining
We have analyzed 59 unrelated Mexican Duchenne/Becker muscular dystrophy patients (DMD/BMD) using PCR analysis of the 2 prone deletion regions in the DMD gene. Thirty one (52%) of the patients had a deletion of one or several of the exons. Most of the alterations (87%) were clustered in exons 44-52,