Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis
β Scribed by M. Vukmanovic-Stejic; A. McQuaid; K.E. Birch; J.R. Reed; C. Macgregor; M.H.A. Rustin; A.N. Akbar
- Book ID
- 108668242
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 237 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0007-0963
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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d
## Abstract ## BACKGROUND Active suppression by CD4^+^CD25^+^ regulatory T cells plays an important role in the downβregulation of the response of T cells to foreign and self antigens. Experimental tumor models in mice revealed that regulatory T cells inhibit antitumor immune responses. The purpos