✦ LIBER ✦

Relative bioavailability of acetazolamide tablets

✍ Scribed by Arthur B. Straughn; Ramachander Gollamudi; Marvin C. Meyer

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 395 KB
Volume: 3
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510030110

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Plasma acetazolamide concentrations were determined enzymatically after administration of three tablet dosage forms and a reference solution to 12 human subjects in a crossover study. Two of the tablet products represented different lots from the same manufacturer. There were no significant differences in area under the plasma level‐time curves among the four treatments. However, significant differences were found among tablets in terms of peak plasma concentration and time to reach peak concentration. These apparent differences in rate of absorption were correlated with in vitro dissolution data obtained in pH 1.5 dissolution medium.

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