✦ LIBER ✦

Comparative bioavailability study of two tablet formulations of cimetidine

✍ Scribed by R. R. Berardi; I. A. Cohen; M. L. Hyneck; G. F. Lockwood; U. A. Shukla; E. Sakmar; J. J. Wells; Dr. J. G. Wagner

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 378 KB
Volume: 5
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510050210

No coin nor oath required. For personal study only.

✦ Synopsis

A two-way crossover bioavailability study of two commercial cimetidine formulations was performed on 24 healthy male volunteers. Drug was administered after an overnight fast and plasma samples were withdrawn periodically for 12 h. Urine was collected throughout the study period. Results indicated that the two formulations were bioequivalent since no statistically significant dinerence in means was detected for any of the parameters studied. Extensive interpatient variation in cimetidine blood concentration was observed during both treatments.

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