✦ LIBER ✦

The relative bioavailability of a commercial propranolol hydrochloride tablet in man

✍ Scribed by R. Roscoe; J. Cooper; T. W. Wilson; N. N. Joshi; K. K. Midha

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 412 KB
Volume: 3
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510030204

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A relative bioavailability study of a conventional tablet of propranolol hydrochloride was conducted in a group of 18 healthy volunteers employing the innovator's product as the reference tablet formulation. Based on plasma levels of propranolol for the 24 h following administration of 2 ± 40 mg oral propranolol hydrochloride tablets, the relative extent of bioavailability was shown to be 100.8 per cent for the test tablet formulation; no significant differences were detected between formulations with respect to any of the pharmacokinetic parameters examined. Large intersubject variations in plasma propranolol concentrations and the subsequently calculated areas under the plasma concentration/time curves were attributed to substantial presystemic biotransformation differences.

📜 SIMILAR VOLUMES

RELATIVE BIOAVAILABILITY OF FOUR CLOMIPR

RELATIVE BIOAVAILABILITY OF FOUR CLOMIPRAMINE HYDROCHLORIDE TABLET PRODUCTS

✍ F. O. Müller; R. Schall; E. M. Mogilnicka; G. Groenewoud; H. K. L. Hundt; H. G. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

The relative bioavailability of clomipramine was determined in two single-blind, singledose, randomized, crossover studies. In the first study, the relative bioavailability of the test product, 2 x 25mg clomipramine hydrochloride tablets (Noristan Ltd.), with respect to the reference product, Anafra

Bioavailability of propranolol hydrochlo

Bioavailability of propranolol hydrochloride tablet formulations: Application of multiple dose crossover studies

✍ Dr. Michael A. Eldon; Arlyn W. Kinkel; Jane E. Daniel; Jeffrey R. Latts 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB 👁 2 views

Two multiple dose crossover pharmacokinetic studies were carried out to determine the steady-state bioavailability of newly formulated generic propranolol HCI tablets relative to lnderalo tablets. In Study I, 24 healthy volunteers were dosed with 4 x lOmg test tablets, 1 x 40 mg test tablet, 4 x 10

In vitro and in vivo assessment of the b

In vitro and in vivo assessment of the bioavailability of potassium from a potassium tartrate tablet

✍ Susan J. Whiting; Dennis K. J. Gorecki; Dennis Jones 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 1 views

The bioavailability of potassium from orally administered potassium tartrate was evaluated in 20 normal subjects under metabolic balance conditions. Subjects were given 34 mmol potassium (5 tablets of Cal-K@) as a divided dose on each of 2 consecutive days. Urinary excretion of potassium, as determi

Allopurinol: A comparative study of the

Allopurinol: A comparative study of the bioavailability and effect on plasma uric acid of two products in tablet form

✍ Poul Nissen; Linda Pedersen 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB 👁 2 views

A comparative bioavailability study was carried out with two allopurinol products, i.e. Allopurinol tablets 100 mg, DAK, and ApurinB tablets 100 mg, Gea. Eleven healthy volunteers participated and were given a single dose of 200 mg of each product according to the cross-over principle. The bioavaila

Comparative bioavailability of josamycin

Comparative bioavailability of josamycin, a macrolide antibiotic, from a tablet and solution and the influence of dissolution on in vivo release

✍ M. Skinner; I. Kanfer 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB 👁 2 views

The bioavailability of josamycin from a tablet formulation (2 × Josacine ® 500 mg tablets) was investigated and compared with the bioavailability of a solution (containing 1 g drug and buffered at pH 4.0) following administration to six healthy human volunteers. Bioavailability profiles for the solu

The use of saliva as a biological fluid

The use of saliva as a biological fluid in relative bioavailability studies: comparison and correlation with plasma results

✍ M. Esperanza Ruiz; Paula Conforti; Pietro Fagiolino; M. Guillermina Volonté 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 1 views