A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an
Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors
✍ Scribed by Markgren, Per-Olof; Schaal, Wesley; Hämäläinen, Markku; Karlén, Anders; Hallberg, Anders; Samuelsson, Bertil; Danielson, U. Helena
- Book ID
- 121878607
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 257 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2623
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