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Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

✍ Scribed by Cynthia F. Shuman; Per-Olof Markgren; Markku Hämäläinen; U.Helena Danielson

Book ID
114144503
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
331 KB
Volume
58
Category
Article
ISSN
0166-3542

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📜 SIMILAR VOLUMES

Kinetic and thermodynamic characterizati
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors
✍ Cynthia F. Shuman; Markku D. Hämäläinen; U. Helena Danielson 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 716 KB

Interaction kinetic and thermodynamic analyses provide information beyond that obtained in general inhibition studies, and may contribute to the design of improved inhibitors and increased understanding of molecular interactions. Thus, a biosensor-based method was used to characterize the interactio

Kinetic Analysis of the Interaction betw
Kinetic Analysis of the Interaction between HIV-1 Protease and Inhibitors Using Optical Biosensor Technology
✍ Per-Olof Markgren; Markku Hämäläinen; U.Helena Danielson 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 97 KB

The interaction between HIV-1 protease and reversible inhibitors was studied by surface plasmon resonance biosensor technology. The steady-state binding level and the time course of association and dissociation could be observed by measuring the binding of inhibitors injected in a continuous flow of