## Abstract The aim of the study was to describe the pattern of resistance mutations in human immunodeficiency virus type 1 (HIVβ1) infected patients experiencing their first protease inhibitor (PI) failure on nelfinavir (NFV)βcontaining therapy. Earlier PIβnaΓ―ve patients (nβ=β172) with NFVβcontain
A Multivariate Analysis of HIV-1 Protease Inhibitors and Resistance Induced by Mutation.
β Scribed by Anna Maria Almerico; Marco Tutone; Antonino Lauria; Patrizia Diana; Paola Barraja; Alessandra Montalbano; Girolamo Cirrincione; Gaetano Dattolo
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
This work presents a chemometric classification for a set of 24 known HIV-1 protease inhibitors, based on two pattern recognition methods widely used in quantitative structure-activity (QSAR) studies: soft independent modeling of class analogy (SIMCA) and Kth nearest neighbors (KNN) with the aim of
## Abstract For Abstract see ChemInform Abstract in Full Text.
The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure.