Relationship of p21 (waf1/cip1) and differentiation in chondrosarcoma cells
โ Scribed by Koji Hiraoka; Michihisa Zenmyo; Setsuro Komiya; Rikimaru Kawabata; Masahiro Yokouchi; Ritsu Suzuki; Tetsuya Hamada; Seiya Kato; Kensei Nagata
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 146 KB
- Volume
- 440
- Category
- Article
- ISSN
- 1432-2307
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti
The immunoreactivity of p21 was evaluated in normal mucosa and in adenomas and adenocarcinomas of the human large bowel. In normal mucosa, p21 immunoreactivity was seen in the superficial third of the crypts (maturation compartment) and in surface (terminally differentiated) epithelium, and was mutu
In addition to the tumor suppressor gene p53, Cyclin Dependent Kinases (CDK) are well known to influence the cell cycle in normal human tissues and various neoplasias as well. The purpose of our present study was to evaluate the expression of the CDK-inhibitor p21/waf1/cip1 in colorectal cancer with
## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s